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3 edition of Chromosome 12 Aberrations in Human Solid Tumors found in the catalog.

Chromosome 12 Aberrations in Human Solid Tumors

Jorn Bullerdiek

Chromosome 12 Aberrations in Human Solid Tumors

Cytogenetics and Molecular Genetics

by Jorn Bullerdiek

  • 110 Want to read
  • 27 Currently reading

Published by Springer-Verlag Telos .
Written in English


The Physical Object
Number of Pages194
ID Numbers
Open LibraryOL7447132M
ISBN 100387557598
ISBN 109780387557595

Like solid tumors, CML accumulates new genetic aberrations throughout its course and eventually reaches a stage where therapy targeted against its driving aberration has markedly reduced effectiveness. It is our contention that CML blastic phase Cited by: 2.   There are a number of important cancer-related genes located on this chromosome, including Anxa7 (annexin 7, its human counterpart ANXA7 located on HSA10q21), which is a tumor suppressor gene associated with prostate cancer and Bmp4, Lgals3 and Cdkn3, whose human counterparts are located on chromosome band 14q22 in by: 4. T1 - Oncogenes and tumor suppressor genes in malignant mesothelioma. AU - Kratzke, Robert A. AU - Gazdar, Adi F. PY - /12/1. Y1 - /12/1. N2 - Conclusion: Mesothelioma is a cancer marked by a distinct pattern of mutations unlike most other solid : Robert A. Kratzke, Adi F. Gazdar.   Increasing attention is focusing on chromosomal and genome structure in cancer research due to the fact that genomic instability plays a principal role in cancer initiation, progression and response to chemotherapeutic agents. The integrity of the genome (including structural, behavioral and functional aspects) of normal and cancer cells can be monitored with Cited by:


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Chromosome 12 Aberrations in Human Solid Tumors by Jorn Bullerdiek Download PDF EPUB FB2

Chromosome 12 Aberrations in Human Solid Tumors: Medicine & Health Science Books @ Chromosome 12 Aberrations in Human Solid Tumors Cytogenetics and Molecular Genetics. Editors (view affiliations) Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections.

Chromosome 12 Aberrations in Human Solid Tumors Cytogenetics and Molecular Genetics. Editors: Bullerdiek, Jörn, Bartnitzke, Sabine (Eds.) Free Preview. Comparative gene mapping: human chromosome 12 and mouse chromosome 15 / H. Hameister [and others] --Molecular oncology of 12q / B.

Rommel, J. Bullerdiek, W. Schloot --Gene analysis: methods and facts --Cell lines from tumors showing 12q aberrations / B. Kazmierczak [and others] --Analysis of DNA from a specific chromosome region / N. Get this from a library. Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics.

[J Bullerdiek; S Bartnitzke] -- Researchers involved in the cytogenetics and molecular genetics of human tumors will welcome this comprehensive overview of the type of aberrations that chromosome 12 presents in human solid tumors.

Suijkerbuijk R.F. et al. () Chromosome 12 Aberrations in Human Germ Cell Tumors: A Fluorescence In Situ Hybridization Inventory. In: Bullerdiek J., Bartnitzke S. (eds) Chromosome 12 Aberrations in Human Solid : R.

Suijkerbuijk, R. Sinke, L. Looijenga, B. de Jong, J. Oosterhuis, J. Cassiman, A. The concept of errors in cell division resulting in abnormal chromosome complements responsible for cancer development was first proposed by Boveri in 14 The landmark observation by Tjio and Levan in 15 confirmed the presence of 46 chromosomes in normal human cells.

InNowell and Hungerford16, 17 identified a recurrent deleted chromosome in patients with Cited by:   CHROMOSOME 8. Alterations of human chromosome 8p have been commonly detected in many tumor types[].Some studies have shown that loss of 8p is associated with the advance of tumors, and plays an important role in the tumor progression of many tumors including colorectal[], bladder[14,15], breast[] and liver cancers[].Recently, some studies have Cited by:   The aberrations of chromosome 12 which the e-book bargains with are very common chromosomal changes in human tumors occuring in widespread benign mesenchymal tumors, corresponding to uterine leiomyomas and lipomas, and in tumors of epithelial foundation, reminiscent of pleomorphic adenomas of the salivary glands/5(39).

4 Cancer Ploidy and Chromosome Aberration Rates. Solid tumors with a chromosome number between triploid (n = 69) and tetraploid (n = 92) have been estimated to occur in some 30 % of all epithelial cancers (Storchova and Kuffer ).As it is unlikely that chromosome missegregation alone occurs at sufficiently high rates to explain how cancer cells achieve such pseudo Cited by: Chromosome aberrations in solid tumors Donna G Albertson 1,2, Colin Collins 1,2, Frank McCormick 1,3 & Joe W Gray 2,4 Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability.

This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms. Chromosomal aberrations are a common feature of human cancers, are more pronounced in solid tumors than hematologic cancers and occur with consistency in malignant melanomas 11.

Patterns of Chromosomal Aberrations in Solid Tumors recommended to screen AO patients for these chromosom al aberrations (Anderson and Gilbert ; Polivka et al. Numerical disorders.

This is called aneuploidy (an abnormal number of chromosomes), and occurs when an individual either is missing a chromosome from a pair (monosomy) or has more than two chromosomes of a pair (trisomy, tetrasomy, etc.).

An example of trisomy in humans is Down syndrome, which is a developmental disorder caused by an extra copy of chromosome. Stark, B, Mor, C, Jeison, M, et al. Additional chromosome 1q aberrations and der(16)t(1;16), correlation to the phenotypic expression and clinical behavior of the Ewing family of tumors.

J Neurooncol ; 3 – by: 1. DISCUSSION It is an important result of the last decade of chromosome studies in human tumors that benign tumors can show typical or even specific chromosome aberrations as well.

The first specific aberration found in a benign tumor was monosomy 22 in meningiomas [11, Cited by: XVII- Primary and secondary chromosome aberrations.

Secondary aberrations may enable survival of an otherwise lethal unbalanced product. Examples: Additional isochromosomes deriving from a trisomy. - Correction of trisomy through uniparental disomy. - Secondary structural aberrations with loss of a chromosomal segment following a trisomy.

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.5/5(2).

Research on DNA and chromosome aberrations focuses on cancer genetics and epigenetics. Topics include regulation of gene expression; DNA damage from exposure to chemical, physical, and endogenous agents; mechanisms of DNA damage signaling and DNA repair; and genomic instability and related molecular, cytogenetic, and chromosomal effects during tumor formation.

Targeted Therapies for Solid Tumors A Handbook for Moving Toward New Frontiers in Cancer Treatment C. Cancer Treatment. Follow. 4 years ago | 0 view. Targeted Therapies for Solid Tumors A Handbook for Moving Toward New. ferent types of spindle cell tumors cannot always be distinguished from one another morphologically, particularly when poorly differentiated.

Synovial sarcoma, myxoid liposarcoma, and extraskeletal myxoid chondrosarcoma are all associated with specific translocations—t(X;18)(p;q) in synovial sarcoma (); t(12;16)(q13;p11) in myxoid. Boveri proposed that cancer originates in a single cell by mitotic disturbances resulting in chromosome aberrations.

Through subsequent cell divisions, this acquired genetic change is propagated to all daughter cells. And as a consequence, all cells in a cancer carry the genetic abnormality that initiated this process. This remarkably prescient idea still today. (2) Numerical and structural aberrations of chromosome 1 have been found in many solid tumors (Atkin ).

(3) Aber- rations of chromosomes 1 and 18 have been previously noted in TC and TC by in situ hybridization with subregional DNA probes specific for lq12 and the pericentromeric hetero. Heredity - Heredity - Chromosomal aberrations: The chromosome set of a species remains relatively stable over long periods of time.

However, within populations there can be found abnormalities involving the structure or number of chromosomes.

These alterations arise spontaneously from errors in the normal processes of the cell. Their consequences are usually. specific chromosomal aberrations in solid tumors - new insights in the pathogenesis of malignant 12 in chronic lymphatic leukemia (Losada et al., ; Anastasi et al., ) or trisomy 8 in myeloic leukemia samples was the introduction of chromosome libraries which "paint" a whole chromosome thus allowing the.

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.

ADVERTISEMENTS: Aberration alters the chromosome structure but do not involve a change in chromosome number. The mechanics signify chiefly a rearrangement through loss, gain or reallocation of chromosomal segments.

In normal course of cell-division cycle, the chromosomes duplicate and segregate in an orderly manner. The sequence of gene loci in the chromosome.

Chapter in an edited book. Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. In analogy, most malignant tumours exhibit both structural and numerical chromosome abnormalities (Mitelman Database of Chromosome Aberrations in Cancer ).

However, in many low-grade mesenchymal and neuroglial tumours, BFB events involving telomeric associations and ring chromosomes are seen at mitosis, in the absence of major numerical. Edwards AA (), The use of chromosomal aberrations in human lymphocytes for biological dosimetry, Radiation ResearchSS Edwards AA (), Modeling radiation-induced chromosome aberrations, International Journal of Radiation Biol @article{osti_, title = {Screening for somatic mutations of the neurofibromatosis genes in nervous system and other solid tumors}, author = {Rangaratnam, S and Narod, S and Ruttledge, M}, abstractNote = {Von Recklinghausen neurofibromatosis (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited disorders which predispose carriers to various benign.

Chromosomal instability (CIN) is a type of genomic instability in which chromosomes are unstable, such that either whole chromosomes or parts of chromosomes are duplicated or deleted. More specifically, CIN refers to the increase in rate of addition or loss of entire chromosomes or sections of them.

The unequal distribution of DNA to daughter cells upon mitosis results in a. Chromosomal aneuploidy, that is to say the gain or loss of chromosomes, is the most common abnormality in cancer.

While certain aberrations, most commonly translocations, are known to be strongly associated with specific cancers and contribute to their formation, most aberrations appear to be non-specific and arbitrary, and do not have a clear effect.

The gene encoding LH-RH-R is located in chromosome 4 (location: 4q); however, the occurrence of numerical aberrations of chromosome 4 have never been studied in UM.

In the present study, we investigated the abnormalities of chromosome 3 and 4, and the possible correlation between them, as well as with LH-RH-R by: 2. T1 - Common chromosomal aberrations detected by array comparative genomic hybridization in specialized stromal tumors of the prostate.

AU - Pan, Chin Chen. AU - Epstein, Jonathan Ira. PY - / Y1 - / N2 - Specialized stromal tumors of the prostate encompass stromal sarcoma and stromal tumors of uncertain malignant potential (STUMP).Cited by: 9.

Trisomy for chromosome 17 was present in one case, and trisomy X was present in two cases. In tissue sections the incidence of signal gain for the chromosome 12 probe varied from % of nuclei (mean 19%). In cytospin preparations, the percentage signal gain for chromosome 12 ranged from 0 to 84% (mean 33%).Cited by: @article{osti_, title = {Leiomyoma of uterus in a patient with ring chromosome Case presentation and literature review}, author = {Hajianpour, M J and Habibian, R and Hajianpour, A K}, abstractNote = {We report on a year-old woman with de novo ring chromosome 12 mosaicism, 46,XX,r(12)(pq)/46,XX.

In addition to the clinical manifestations generally. 12 Tumors of the upper aerodigestive tract Susanne M. Gollin. 13 Tumors of the lung Penny Nymark, Eeva Kettunen and Sakari Knuutila. 14 Tumors of the digestive tract Georgia Bardi and Sverre Heim. 15 Tumors of the urinary tract Paola Dal Cin.

16 Tumors of the breast Manuel R. Teixeira, Nikos Pandis and Sverre Heim. This text presents a comprehensive and updated catalogue of the already large, and rapidly growing number of chromosome aberrations in man.

The consistent structure of the text and references provide for rapid orientation. The catalogue should prove useful for any clinician treating patients with autosomal chromosome aberrations as well as for physicians and 5/5(2). and Chromosome Damage and Repair Chapter 2 Eric J.

Hall., Amato Giaccia, induced chromosome aberrations DNA repair pathways • Mammalian cells have developed a number of specialized pathways to sense and repair • Cells from human tumors have a wide range of. Chromatin Folding, Fragile Sites, and Chromosome Aberrations Induced by Low- and High- LET Radiation Ye Zhang1,2, Bradley Cox1,3, Aroumougame Asaithamby 4, David J.

Chen4 and Honglu Wu1 1NASA Johnson Space Center, Houston, Texas, USA 2 Wyle Laboratories, Houston, Texas, USA 3University of Houston Clear Lake, Houston, Texas, USA 4University of Texas, Author: Ye Zhang, Bradley Cox, Aroumougame Asaithamby, David J.

Chen, Honglu Wu. Current cytogenetics has largely focused its efforts on the identification of recurrent karyotypic alterations, also known as clonal chromosomal aberrations (CCAs). The rationale of doing so seems simple: recurrent genetic changes are relevant for diseases or specific physiological conditions, while non clonal chromosome aberrations (NCCAs) are Cited by: Define chromosomal aberration.

chromosomal aberration synonyms, chromosomal aberration pronunciation, chromosomal aberration translation, English dictionary definition of chromosomal aberration. Noun 1. chromosomal aberration - any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities.